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Ready to accelerate your behavior and neuroscience research?

CI-SHELL is the latest in neuroscience testing.
Simplify animal behavior and neuroscience research by using more socially and environmentally relevant conditions while supporting reliable behavioral monitoring, cognitive research, and long-term activity tracking.

Ask an Expert

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Columbus Instruments designed CI-SHELL (Social Home Environment for Laboratory Learning) to create enriched, controlled social home environments for mice, supporting continuous behavioral and activity monitoring across studies of cognition, interaction, learning, behavior, and neurology.

All set in more natural and socially relevant housing conditions to provide a flexible platform for long-term behavioral studies while minimizing animal disruption and simplifying data collection.
  • Controlled social home environments 
  • Continuous activity and behavioral monitoring 
  • Designed for group-housed rodent studies 
  • Supports long-term experiments with minimal disruption 
  • Flexible configurations for different research applications 
  • Helps create more naturalistic housing conditions 
  • Easy-to-use monitoring and data collection systems 
Why Columbus Instruments CI-SHELL?
  • Food & Water Consumption:
    Customize the perimeters of your experiment and choose one as a reward, use them interchangeably; unique to CI-SHELL.
  • RFID Tracking:
    RFID implants work with antenna baseplates to identify subjects entering each conditioning corner for RFID mouse activity monitoring. Only CI-SHELL has the ability to get generalized position information in the social area of the cage.
  • Access Control:
    Limit access to certain programmed conditioning corners.
  • Electrical Stimulus & Air Puff Stimulus:
    Choose between two types of stimuli. Program them directly into the CI-Link software; only available in CI-SHELL.  
  • LED:
    Program any light color as a conditioned stimulus to help subjects associate a specific color with a particular action, such as access to a reward.
  • Software Individualization:
    Set up conditioning corners on a per-subject basis using CI-Link software. 

Optimize Your Research with CI-SHELL

CI-SHELL can be used for a variety of different behavioral and neuroscience studies.
High-Level Research Fields & Disease Models

Fields of study, clinical goals, and specific neurological conditions.

  • Neuroscience
    • Behavioral Neuroscience Research
    • Brain and Behavior Research
    • Neurobehavioral Research Animals
    • Preclinical Neuro Research / Translational Neuroscience Research
  • Clinical & Disease Models
    • Addiction Research
    • Pre-Clinical Alzheimer's Research
    • Pre-Clinical Anxiety Research / Pre-Clinical Anxiety Testing
Cognitive, Learning, & Memory Paradigms

Assess brain function related to memory, decision-making, flexibility, and spatial awareness.

Learning & Executive Function

  • Animal Behavior Analysis
  • Cognitive Learning (Mouse / Mice / Rodent Cognitive Learning Environment)
  • Learning and Memory Research in Rodents
  • Attention Set Shifting Task
  • Reversal Learning / Reversal Learning Task (Mouse / Mice)

Spatial Learning & Memory Tests

  • Pre-Clinical Spatial Learning
  • Morris Water Maze
  • Radial Arm Maze
  • Y Maze Test
Emotional, Anxiety, & Reward Testing

Measure neuropsychological states like anxiety, fear, motivation, and preference.

  • Elevated Plus Maze (Measures Anxiety)
  • Open Field Test (Measures Anxiety and Exploration)
  • Fear Conditioning Test (Measures Associative Memory and Fear)
  • Novel Object Recognition Test (Measures Recognition Memory)
  • Place Preference (Often Used in Addiction and Reward Research)
Operant Conditioning & Attention Tasks

Test animal interaction with a stimulus, utilizing levers, nose-pokes, and automated rewards.

  • Operant Conditioning Chamber (Skinner Box)
  • Home Cage Operant Conditioning (Mouse / Mice)
  • Five Choice Serial Reaction Time Task *(Measures Sustained Attention and Impulsivity)
Social Behavior & Social Learning

Monitor how rodents interact with one another, share social cues, or learn from peers.

  • Three Chamber Social Test
  • Social Interaction Tracking Rodent / Mice Social Testing (Mouse)
  • Mice Social Conditioning (Mouse)
  • Mice Social Food Behavior / Mice Social Food Preference (Mouse)
Automated Phenotyping & Monitoring Systems

Collect continuous, long-term data without human interference using the latest hardware, software, and tracking technology.

System Types

  • Behavioral Phenotyping Systems / Behavioral Phenotyping Equipment
  • Automated Behavioral Phenotyping
  • Rodent Metabolic Phenotyping
  • Group Mouse Environment / Group-Housed Rodent Tracking System

Home Cage Technologies

  • Automated Home Cage Monitoring / Social Home Cage Monitoring
  • RFID Mouse Activity Monitoring
  • Automated Mouse Consumption Monitoring / Automated Rodent Feeding System Cost

Product Description

The Comprehensive Lab Animal Monitoring System (Oxymax-CLAMS) is the premier solution for advanced laboratory research. This state-of-the-art system integrates an array of unique features for open circuit calorimetry and detailed subject analysis, providing a one-stop solution for simultaneous multi-parameter assessment of multiple test subjects at once. Built on a semi-custom basis, Oxymax-CLAMS can be tailored to include parameters specific to your research needs. The system is fully expandable, allowing for additional chambers and features for the evolving demands of your research. The included software, CI-Link, offers an intuitive interface for collecting and managing all experimental data, which can be easily exported for analysis or publication. Researchers can view data graphically in real-time without interrupting the experiment.

Key Features

Food & Water Consumption
  • Configured each conditioning corner to be either a food or a water reward
  • Continuously monitor reward consumption, record both the amount consumed and the timing of each event
  • Interchange the food and water reward modules within each conditioning corner
Access Control
  • Each conditioning corner has automated access-control doors for food and water rewards
  • Access is programmable on an individual animal basis to support a variety of learning, preference, and behavioral paradigms
LED
  • Program each conditioning corner with three independent LEDs
  • Configure the LEDs to display any RGB color
RFID Tracking
  • Identify subjects using subcutaneous RFID microchips that can be implanted without anesthesia
  • Track subject location within the social area and conditioning corners using an integrated RFID antenna array within the CI-SHELL baseplate to wirelessly communicate with each microchip
Electrical Stimulus / Air Puff Stimulus
  • Program either an electrical or an air-puff stimulus for behavioral conditioning studies
  • Select the electrical stimulus intensity within the CI-Link software
  • Configure stimuli delivery independently for each subject and conditioning corner
Dimensions
  • 19'L x 15'W x 15'H
  • 16.78 kg

Key Maintenance Information

RFID Microchips
  • Implant without anesthesia
  • Use the supplied identification wand to track subjects implanted with RFID microchips to prevent mismatching and track subjects between studies
Cleaning
  • The stainless-steel metalwork and base cage are machine washable for easy cleaning
  • Other components are removable for separate hand washing

Frequently Asked Questions - FAQs

How does the system measure activity?

When a subject moves over an RFID antenna within the baseplate, its position is recorded. These positional data are used to generate a heatmap for the subject.

How are individual animals identified in a group-housed setting?

Each animal is implanted with a subcutaneous RFID microchip containing a unique identification number. The microchip can be implanted without anesthesia, allowing the system to automatically identify individual animals throughout the study.

How is reward consumption individualized between subjects?

When a subject enters a conditioning corner, all reward consumption events are associated with that animal's unique RFID identification. This allows individual food and water intake data to be collected in the group setting.

Can different diets be offered within a single CI-SHELL system?

Yes, different food types can be placed in separate conditioning corners, allowing researchers to study food preference and dietary choice.

What behavioral paradigms can CI-SHELL support?

CI-SHELL is highly configurable and supports a variety of behavioral applications, including:

  • Operant conditioning  
  • Reward-based learning  
  • Preference testing  
  • Circadian behavior studies  
  • Social interaction research  
  • Feeding motivation studies  
  • Cognitive flexibility tasks  
  • Resource competition studies  
  • Environmental enrichment research
How often is data collected?

Data is collected continuously throughout the study. CI-SHELL is designed as a home-cage environment, enabling long-term monitoring with minimal disruption to natural animal behavior.

What species are supported?

CI-SHELL is currently designed for mice but may be adaptable for other small laboratory animal species depending on study requirements.

Does bedding interfere with RFID communication?

No, CI-SHELL's RFID system is designed to operate through standard laboratory bedding materials. Normal bedding levels do not interfere with RFID communication or animal identification.

Noisy Activity Data

DaCheck for bedding/debris blocking the IR beams in the metabolic and behavioral cages.ily

Food Intake Spikes

Ensure the metabolic cage housing system spill cup isn't touching the cage floor (zeroing the scale).

Drifting Gas Signal

Check the lab animal monitoring system pump flow rate; ensure it matches your calibration.

Can CI-SHELL track social interactions?

Yes, the system continuously records animal location, allowing researchers to evaluate social behaviors within the cage.

Can researchers restrict access to specific resources?

Yes, access-control doors can be programmed for individual animals, allowing researchers to control which subjects can access specific food, water, or conditioning areas.

How long can animals remain in CI-SHELL?

CI-SHELL is designed as a home cage for long-term studies, depending on the study’s needs.

Can visual cues be incorporated into experiments?

Yes, each conditioning corner contains programmable RGB LEDs that can be used as visual cues for learning and discrimination experiments.

Transform the way you study behavior.

CI-SHELL combines enriched social housing with continuous monitoring to provide researchers with deeper behavioral insights in more representative living conditions. See what's possible with a smarter research platform.