Oxymax-CLAMS

Dependable Humidity Control for Consistent Results

Building on a tradition of precise humidity management, Oxymax features a cutting-edge 2-stage sample drying method that effectively eliminates all moisture from air samples. This advanced approach ensures that only oxygen, carbon dioxide, and nitrogen are measured, adhering to the best practices for indirect calorimetry in research and preventing humidity from skewing recorded oxygen values.

Rapidly removing humidity can pose a significant engineering challenge. While humidity correction—measuring and back-calculating humidity—may seem like a simpler alternative, it relies on stable temperatures and often fails during rapid fluctuations. In experiments with manipulated ambient temperatures, the humidity correction technique lacks proper temperature compensation to accurately track VO2, leading to questionable RERs. Oxymax’s precision-engineered drying method is the best on the market that ensures accurate oxygen tracking regardless of temperature changes, delivering reliable O2/CO2 measurements while matching or exceeding the temporal resolution and data density of humidity corrected systems.

State-of-the-art Metabolic Cage Innovation

Experience the future of metabolic research with CLAMS-CN, a groundbreaking system that streamlines setup by eliminating tubes and wires. Its innovative design removes the risk of common setup errors, saving valuable time and effort, while simplifying the entire process for a faster, more efficient workflow. No more double-checking cables —just fast, efficient results.

The Connect Cage also offers the highest level of flexibility, with autoclaveable parts, in-cage measurements of temperature, humidity, pressure, and sound levels, and electronics safe for vapor sterilization (H2O2 or EthO). Its P3 biocontainment rating configuration makes it perfect for virology or gnotobiotic research, and it is suitable for hypoxia studies down to 10% oxygen. Elevate your research with precision and convenience, all in one innovative solution.

Innovative Energy Expenditure Analysis: Clambake

Traditional research often stops at measuring overall energy expenditure, but Clambake advances this approach. Developed by the Brestoff Lab at Washington University in St. Louis, this cutting-edge algorithm categorizes energy expenditure into four key components: Basal Metabolic Rate (BMR), Thermic Effect of Food (TEF), Activity-Induced Energy Expenditure, and Adaptive Thermogenesis. By analyzing data from Oxymax-CLAMS, Clambake provides advanced insights into metabolic rates, deepening the understanding of fundamental energy metabolism processes.

High-Precision C13 Isotopic Analysis

Address your substrate utilization tracking challenges with our advanced solution for simultaneous measurement of 13CO2, O2, and CO2. By integrating Picarro's stable isotope analyzer with our CI-Link software, we offer a seamless in-line measurement system with great accuracy. Our solution ensures exceptional performance with >0.1 0/00 precision and a 200 ppb range, providing reliable data for your metabolic research needs. Additionally, the Picarro combustion module add-on enables precise recovery of carbon isotopic compositions from harvested tissues.

Animal Welfare Monitoring: Adhering to Best Laboratory Principles

Introducing a new feature for the CLAMS-Connect environmental enclosure: in-cage cameras that deliver live feeds directly through CI-Link software. This enhancement allows for 24-hour welfare monitoring without needing to open the enclosure or rely on outdated methods like films or one-way glass. Stay tuned for upcoming push notifications for welfare alerts!

Accurate Heart Rate and Core Body Temperature Monitoring

Our telemetry system leverages advanced technology to provide precise biomarker data through a wireless, battery-less implant. Unlike traditional systems that require bulky batteries and frequent maintenance, our G2 Emitters—available for core body temperature and heart rate, or core temperature only—utilize wireless power transmitted via a custom antenna located less than 2mm beneath the cage floor. This design allows for extended use with a 2-year warranty, significantly reduces operational costs, and supports continuous high-density data collection without the limitations of battery life. While the system currently supports basic biomarkers, metabolic cages can be customized to integrate telemetry systems from other manufacturers for additional capabilities. Contact our sales team for more information.

Advanced Liquid Consumption Measurement

For enhanced accuracy in lick detection, the Volumetric Drinking Monitor (VDM) provides microliter precision. Leveraging a patented conductivity principle for liquid delivery, the VDM performance is carefully calibrated to ensure optimal performance with a variety of liquids, including water, sucrose, and even specialized solutions like Ensure. This precise calibration guarantees reliable and consistent results across different research applications.

Advanced Methane Detection

Columbus Instruments has teamed up with Horiba, a leader in low-range methane detection, to provide integrated methane analysis in conjunction with oxygen and carbon dioxide measurements for the Oxymax system. This enhancement effectively addresses the challenges of researching methane and hydrogen-producing microbiota in the gastrointestinal tract of rodents.