Analgesia Testing
Better understand pain mechanisms and management strategies.
Tail Flick Testing
- The system uses a heat stimulus lamp and records the time for the subject to flick or withdraw in response. By measuring this sensory response, the system offers a reliable method for evaluating pain perception, thermal pain thresholds, and the effectiveness of analgesic treatments. It is an essential tool for researchers studying pain sensitivity, analgesia, and the impact of drugs on the nervous system.
Hot Plate Analgesia Meter
- Our Hot Plate Analgesia Meter is an advanced tool for swiftly and effectively assessing analgesia levels. Researchers can precisely gauge pain thresholds and analgesic effects by observing the reaction to a controlled hot surface.
Applications
Features / Specifications
Tail Flick Testing
- Timer Resolution: 0.1 seconds
- Testing Area Dimensions: 19” x 13” (48 cm x 33 cm)
- Lamp Intensity Settings: 25 adjustable settings
- Detection Methods: Manual via footswitch or automatic with photocell
- Data Output: USB or RS-232 for PC connection
Hot Plate Analgesia Meter
- Surface Temperature Range: 30°C to 79.9°C, precisely controlled to within 0.25°C across the plate
- Size of Heated Surface: 10” x 10” x 0.75” (254 mm x 254 mm x 19 mm)
- Temperature Accuracy: ± 0.1°C
- Surface Material: Hard Black Anodized Aluminum
- Accuracy of Timer: 0.1 seconds
Precise Temperature Control and Efficient Data Handling
The Hot Plate Analgesia Meter provides researchers with a stable, evenly controlled temperature surface, maintained by a durable anodized aluminum plate and a built-in digital thermometer, ensuring accurate and consistent results for pain relief studies. Additionally, the meter features a highly accurate digital timer and an RS-232 serial port, allowing precise tracking and recording of animal response times. The included serial cable and software package streamline data collection and integration, making it easy to transfer data to a personal computer for efficient analysis.
Hands-Free Operation
The meter includes a remote footswitch for effortless, hands-free operation, allowing researchers to start and stop the test sequence with ease. This feature enhances convenience and efficiency, enabling rapid response and precise control. It is particularly useful for halting the system immediately when the subject shows signs of discomfort, such as paw or foot licking.
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Tail Flick Testing
- The system uses a heat stimulus lamp and records the time for the subject to flick or withdraw in response. By measuring this sensory response, the system offers a reliable method for evaluating pain perception, thermal pain thresholds, and the effectiveness of analgesic treatments. It is an essential tool for researchers studying pain sensitivity, analgesia, and the impact of drugs on the nervous system.
Hot Plate Analgesia Meter
- Our Hot Plate Analgesia Meter is an advanced tool for swiftly and effectively assessing analgesia levels. Researchers can precisely gauge pain thresholds and analgesic effects by observing the reaction to a controlled hot surface.
Applications
This state-of-the-art system integrates unique features for open circuit calorimetry and detailed subject analysis, providing a one-stop solution for simultaneous multi-parameter assessment of multiple test subjects. We build these systems semi-custom, so you can tailor your Oxymax-CLAMS system to include parameters specific to your research needs. The system is fully expandable, allowing for additional chambers and features for the evolving demands of your research. The included software, CI-Link, offers an intuitive interface for collecting and managing all experimental data. You can export the data quickly for analysis or publication. Researchers can view data graphically in real time without interrupting the experiment.
Features and Benefits
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Precision-Driven Calorimetry
The Universal Oxymax Indirect Calorimetry system delivers precise O2 and CO2 measurements in sealed metabolic cages with unmatched accuracy. Its modular design suits both large and small setups, while its fully automated, turnkey system ensures easy maintenance. With adjustable airflow from 0.5 to 3 liters/minute, Oxymax provides optimal resolution or certainty as needed. It captures O2 and CO2 data at 10Hz, offering high-resolution measurements to filter noise and achieve ultra-fast cage response times.
Oxymax supports 3 oxygen sensor types to cover all possible applications. A non-dispersive infrared CO2 sensor virtually eliminates drift, reducing recalibration needs.
Dependable Humidity Control for Consistent Results
Building on a tradition of precise humidity management, Oxymax features a cutting-edge 2-stage sample drying method that effectively eliminates all moisture from air samples. This advanced approach ensures that only oxygen, carbon dioxide, and nitrogen are measured, adhering to the best practices for indirect calorimetry in research and preventing humidity from skewing recorded oxygen values.
Rapidly removing humidity can pose a significant engineering challenge. While humidity correction—measuring and back-calculating humidity—may seem like a simpler alternative, it relies on stable temperatures and often fails during rapid fluctuations. In experiments with manipulated ambient temperatures, the humidity correction technique lacks proper temperature compensation to accurately track VO2, leading to questionable RERs. Oxymax’s precision-engineered drying method is the best on the market that ensures accurate oxygen tracking regardless of temperature changes, delivering reliable O2/CO2 measurements while matching or exceeding the temporal resolution and data density of humidity corrected systems.
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State-of-the-art Metabolic Cage Innovation
Experience the future of metabolic research with CLAMS-CN, a groundbreaking system that streamlines setup by eliminating tubes and wires. Its innovative design removes the risk of common setup errors, saving valuable time and effort, while simplifying the entire process for a faster, more efficient workflow. No more double-checking cables —just fast, efficient results.
The Connect Cage also offers the highest level of flexibility, with autoclaveable parts, in-cage measurements of temperature, humidity, pressure, and sound levels, and electronics safe for vapor sterilization (H2O2 or EthO). Its P3 biocontainment rating configuration makes it perfect for virology or gnotobiotic research, and it is suitable for hypoxia studies down to 10% oxygen. Elevate your research with precision and convenience, all in one innovative solution.
Innovative Energy Expenditure Analysis: Clambake
Traditional research often stops at measuring overall energy expenditure, but Clambake advances this approach. Developed by the Brestoff Lab at Washington University in St. Louis, this cutting-edge algorithm categorizes energy expenditure into four key components: Basal Metabolic Rate (BMR), Thermic Effect of Food (TEF), Activity-Induced Energy Expenditure, and Adaptive Thermogenesis. By analyzing data from Oxymax-CLAMS, Clambake provides advanced insights into metabolic rates, deepening the understanding of fundamental energy metabolism processes.

Temperature and Light Control Solution
Designed for optimal space efficiency, our environmental control cabinet minimizes laboratory footprint while offering scalable sizes to fit your research needs. It provides precise temperature control ranging from 4°C – 35°C (with higher temperatures available upon request), ideal for studies involving temperature fluctuations. The cabinet features programmable LED strips for customizable light control, including color, intensity, and timing, and supports various day/night cycles and non-24-hour clocks to suit diverse experimental requirements.
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Product Description
The Comprehensive Lab Animal Monitoring System (Oxymax-CLAMS) is the premier solution for advanced laboratory research. This state-of-the-art system integrates an array of unique features for open circuit calorimetry and detailed subject analysis, providing a one-stop solution for simultaneous multi-parameter assessment of multiple test subjects at once. Built on a semi-custom basis, Oxymax-CLAMS can be tailored to include parameters specific to your research needs. The system is fully expandable, allowing for additional chambers and features for the evolving demands of your research. The included software, CI-Link, offers an intuitive interface for collecting and managing all experimental data, which can be easily exported for analysis or publication. Researchers can view data graphically in real-time without interrupting the experiment.
Cage Types

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Add-ons
High-Precision C13 Isotopic Analysis
Address your substrate utilization tracking challenges with our advanced solution for simultaneous measurement of 13CO2, O2, and CO2. By integrating Picarro's stable isotope analyzer with our CI-Link software, we offer a seamless in-line measurement system with great accuracy. Our solution ensures exceptional performance with >0.1 0/00 precision and a 200 ppb range, providing reliable data for your metabolic research needs. Additionally, the Picarro combustion module add-on enables precise recovery of carbon isotopic compositions from harvested tissues.
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Animal Welfare Monitoring: Adhering to Best Laboratory Principles
Introducing a new feature for the CLAMS-Connect environmental enclosure: in-cage cameras that deliver live feeds directly through CI-Link software. This enhancement allows for 24-hour welfare monitoring without needing to open the enclosure or rely on outdated methods like films or one-way glass. Stay tuned for upcoming push notifications for welfare alerts!
Accurate Heart Rate and Core Body Temperature Monitoring
Our telemetry system leverages advanced technology to provide precise biomarker data through a wireless, battery-less implant. Unlike traditional systems that require bulky batteries and frequent maintenance, our G2 Emitters—available for core body temperature and heart rate, or core temperature only—utilize wireless power transmitted via a custom antenna located less than 2mm beneath the cage floor. This design allows for extended use with a 2-year warranty, significantly reduces operational costs, and supports continuous high-density data collection without the limitations of battery life. While the system currently supports basic biomarkers, metabolic cages can be customized to integrate telemetry systems from other manufacturers for additional capabilities. Contact our sales team for more information.
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Advanced Liquid Consumption Measurement
For enhanced accuracy in lick detection, the Volumetric Drinking Monitor (VDM) provides microliter precision. Leveraging a patented conductivity principle for liquid delivery, the VDM performance is carefully calibrated to ensure optimal performance with a variety of liquids, including water, sucrose, and even specialized solutions like Ensure. This precise calibration guarantees reliable and consistent results across different research applications.
Advanced Methane Detection
Columbus Instruments has teamed up with Horiba, a leader in low-range methane detection, to provide integrated methane analysis in conjunction with oxygen and carbon dioxide measurements for the Oxymax system. This enhancement effectively addresses the challenges of researching methane and hydrogen-producing microbiota in the gastrointestinal tract of rodents.
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We designed the versatile Exer 3/6 and the advanced Metabolic Treadmill to enhance exercise physiology and metabolism research. The Exer 3/6 Treadmill offers adjustable speed, incline settings, unparalleled control, and flexibility for diverse experimental needs. The Metabolic Treadmill integrates real-time metabolic analysis, allowing for simultaneous measurement of oxygen consumption and carbon dioxide production during exercise. It is ideal for studies on energy expenditure and respiratory exchange. Together, these treadmills provide comprehensive solutions for researchers exploring metabolism and exercise performance with precision and efficiency.
Applications
Treadmill Types
Exer 3/6
Versatile multi-lane treadmill for general exercise and comparison.
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Inclination
- Automatic: -16° to 25° with 0.1° increments
- Manual: -15° to 25° with 5° increments
Belt Speed
- 1.5 m/min to 102.3 m/min
- Acceleration
- Adjustable 0.0 to 25.5 m/min²
Calibration
- Optional automatic belt speed and odometer distance calibration
Stimulus Options
- Electrical: Up to 2.34 mA, 200 ms pulse, 1-3 times/second
- Air-Puff: Up to 40 PSI, 200 ms pulse, 1-3 times/second
- Acceleration
- Adjustable 0.0 to 25.5 m/min²
Stimulus Repetition Rate
- 1, 2, or 3 Hz
Stimulus Voltage
- 117 VAC, 50/60 Hz
Stimulus Current
- Up to 2.34 mA
Dimensions
- 83.8 x 50.8 x 50.8 cm (33.0” x 20.0” x 20.0”)
Metabolic Only Lanes
- 1-4 individually enclosed per motor controller
- Enclosure Dimensions
ExerGait
Belt Speed Range
- 5.0 to 170.5 cm/s
Dimensions
- 69.3 x 26.7 x 63.5 cm (27.3” x 10.5” x 25.0”)
Light Box Dimensions
- 88.9 x 46.4 x 33.1 cm (35.0” x 18.2” x 13.0”)
Metabolic

- Single lane isolated treadmill for paired exercise and metabolic studies.
- Designed with a clear belt and green backdrop for video observation.
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Analgesia Testing